Consumption of whole grains and legumes modulates the genetic effect of the APOA5 -1131C variant on changes in triglyceride and apolipoprotein A-V concentrations in patients with impaired fasting glucose or newly diagnosed type 2 Report as inadecuate




Consumption of whole grains and legumes modulates the genetic effect of the APOA5 -1131C variant on changes in triglyceride and apolipoprotein A-V concentrations in patients with impaired fasting glucose or newly diagnosed type 2 - Download this document for free, or read online. Document in PDF available to download.

Trials

, 15:100

First Online: 01 April 2014Received: 10 June 2013Accepted: 19 March 2014DOI: 10.1186-1745-6215-15-100

Cite this article as: Kang, R., Kim, M., Chae, J.S. et al. Trials 2014 15: 100. doi:10.1186-1745-6215-15-100

Abstract

BackgroundThe apolipoprotein A5 gene APOA5 -1131 T > C polymorphism is associated with mild hypertriglyceridemia in type 2 diabetic subjects, and interacts with dietary fat in the determination of triglyceride concentrations. We examined whether a substitution of whole grains and legumes for refined rice in a high carbohydrate diet about 65% of energy derived from carbohydrate may modify the effect of this variant on changes in apolipoprotein A-V apoA-V and triglyceride concentrations.

MethodsWe genotyped the APOA5 -1131 T > C in individuals with impaired fasting glucose IFG or newly diagnosed type 2 diabetes, who were randomly assigned to either a group ingesting whole grain and legume meals daily or a control group for 12 weeks.

ResultsAfter dietary intervention, we observed significant interactions between the APOA5 -1131 T > C polymorphism and carbohydrate sources whole grains and legumes versus refined rice in the determination of mean percent changes in triglyceride and apoA-V P interactions <0.001 and =0.038, respectively. In the refined rice group n = 93, the carriers of the risk C allele n = 50 showed a greater increase in the mean percent changes of triglyceride and apoA-V than noncarriers after adjusting for HOMA-IR P = 0.004 and 0.021, respectively. The whole grain and legume group n = 92, however, showed a decrease in fasting glucose, HOMA-IR, and triglyceride, and an increase in apoA-V, irrespective of genotype.

ConclusionsThe data showed that the magnitude of the genetic effect of the APOA5 -1131C variant on triglyceride and apoA-V levels was modulated when substituting consumption of whole grains and legumes for refined rice as a carbohydrate source in IFG or diabetic subjects.

Trial registrationClinicalTrials.gov: NCT01784952.

KeywordsAPOA5 -1131 T > C Whole grains and legumes Triglycerides Apolipoprotein A-V AbbreviationsAPOA5Apolipoprotein A5 gene

apoA-VApolipoprotein A-V

apoBapolipoprotein B

BMIBody mass index

BPBlood pressure, CAD, Coronary artery disease

EDTAEthylenediaminetetraacetic acid

HDLhigh-denstiy lipoprotein

HOMAHomeostasis model assessment

hs-CRPHigh sensitivity C reactive protein

IFGImpaired fasting glucose

IRInsulin resistance

LDLlow-density lipoprotein

PUFAPolyunsaturated fatty acid

SFASaturated fatty acid

SNPSingle-nucleotide polymorphism

WHRWaist and hip ratio.

Electronic supplementary materialThe online version of this article doi:10.1186-1745-6215-15-100 contains supplementary material, which is available to authorized users.

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Author: Ryungwoo Kang - Minjoo Kim - Jey Sook Chae - Sang-Hyun Lee - Jong Ho Lee

Source: https://link.springer.com/







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