Experimental and Computational Approach Investigating Burst Fracture Augmentation Using PMMA and Calcium Phosphate CementsReport as inadecuate

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Annals of Biomedical Engineering

, Volume 42, Issue 4, pp 751–762

First Online: 07 January 2014Received: 10 July 2013Accepted: 06 December 2013DOI: 10.1007-s10439-013-0959-3

Cite this article as: Tarsuslugil, S.M., O’Hara, R.M., Dunne, N.J. et al. Ann Biomed Eng 2014 42: 751. doi:10.1007-s10439-013-0959-3


The aim of the study was to use a computational and experimental approach to evaluate, compare and predict the ability of calcium phosphate CaP and poly methyl methacrylate PMMA augmentation cements to restore mechanical stability to traumatically fractured vertebrae, following a vertebroplasty procedure. Traumatic fractures n = 17 were generated in a series of porcine vertebrae using a drop-weight method. The fractured vertebrae were imaged using μCT and tested under axial compression. Twelve of the fractured vertebrae were randomly selected to undergo a vertebroplasty procedure using either a PMMA n = 6 or a CaP cement variation n = 6. The specimens were imaged using μCT and re-tested. Finite element models of the fractured and augmented vertebrae were generated from the μCT data and used to compare the effect of fracture void fill with augmented specimen stiffness. Significant increases p < 0.05 in failure load were found for both of the augmented specimen groups compared to the fractured group. The experimental and computational results indicated that neither the CaP cement nor PMMA cement could completely restore the vertebral mechanical behavior to the intact level. The effectiveness of the procedure appeared to be more influenced by the volume of fracture filled rather than by the mechanical properties of the cement itself.

KeywordsSpine Biomechanics Vertebroplasty Computational Finite element Calcium phosphate Burst fracture Trauma Associate Editor K. A. Athanasiou oversaw the review of this article.

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Author: Sami M. Tarsuslugil - Rochelle M. O’Hara - Nicholas J. Dunne - Fraser J. Buchanan - John F. Orr - David C. Barton -

Source: https://link.springer.com/

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