The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailedReportar como inadecuado

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Journal of Biomedical Science

, 21:27

First Online: 01 April 2014Received: 31 December 2013Accepted: 28 March 2014DOI: 10.1186-1423-0127-21-27

Cite this article as: Alavian, K.N., Jeddi, S., Naghipour, S.I. et al. J Biomed Sci 2014 21: 27. doi:10.1186-1423-0127-21-27


Specific vulnerability and degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the midbrain is the pathological hallmark of Parkinson’s disease. A number of transcription factors regulate the birth and development of this set of neurons and some remain constitutively expressed throughout life. These maintenance transcription factors are closely associated with essential neurophysiological functions and are required ultimately for the long-term survival of the midbrain dopaminergic neurons. The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity. The review will also elucidate the relationship of these factors with life, vulnerability, degeneration and death of mesencephalic dopaminergic neurons in the context of Parkinson’s disease.

Electronic supplementary materialThe online version of this article doi:10.1186-1423-0127-21-27 contains supplementary material, which is available to authorized users.

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Autor: Kambiz N Alavian - Sharmin Jeddi - Sahar I Naghipour - Pegah Nabili - Pawel Licznerski - Travis S Tierney


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