Bilateral symmetry of breast tissue composition by magnetic resonance in young women and adultsReport as inadecuate

Bilateral symmetry of breast tissue composition by magnetic resonance in young women and adults - Download this document for free, or read online. Document in PDF available to download.

Cancer Causes and Control

, Volume 25, Issue 4, pp 491–497

First Online: 30 January 2014Received: 25 July 2013Accepted: 22 January 2014DOI: 10.1007-s10552-014-0351-0

Cite this article as: Hennessey, S., Huszti, E., Gunasekura, A. et al. Cancer Causes Control 2014 25: 491. doi:10.1007-s10552-014-0351-0


BackgroundSome reports suggest that there is a slightly higher frequency of breast cancer in the left breast compared with the right in middle-aged women. The reasons for this association are unknown. The water and fat content of both breasts was compared using magnetic resonance MR. Breast water by MR reflects fibro-glandular tissue and is strongly positively correlated with percent mammographic density, a strong risk factor for breast cancer.

MethodsMagnetic resonance was used to measure fat and water content of the breast in 400 young women aged 15–30 years and a random sample of 100 of their mothers. All MR examinations were carried out using a 1.5T MR system, and 45 contiguous slices were obtained in the sagittal plane. One reader identified the breast tissue in the image, and subsequently, fat and water content was calculated using a three-point Dixon technique. Left- and right-sided images were read independently in random order.

ResultsIn young women, mean percent water was on average 0.84 % higher in the right compared with the left breast p < 0.001 and total breast water was on average 6.42 cm greater on the right side p < 0.001. In mothers, there were no significant differences in any breast measure between right and left sides.

ConclusionThe small differences in breast tissue composition in young women are unlikely to be associated with large differences in breast cancer risk between sides. The reported excess of left-sided breast cancer in older women is unlikely to be explained by differences in breast tissue composition.

KeywordsBreast cancer risk factor Breast tissue composition Magnetic resonance measurements  Download fulltext PDF

Author: S. Hennessey - E. Huszti - A. Gunasekura - A. Salleh - L. Martin - S. Minkin - S. Chavez - N. F. Boyd


Related documents