Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancerReport as inadecuate




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BMC Cancer

, 14:237

Translational oncology

Abstract

BackgroundBreast cancer is a heterogeneous disease that can be classified into one of 4 main molecular sub-types: luminal A, luminal B, Her2 over-expressing and basal-like BL. These tumour sub-types require different treatments and have different risks of disease progression. BL cancers can be considered a sub-group of Triple negative TN cancers since they lack estrogen ER, progesterone PR and Her2 expression. No targeted treatment currently exists for TN-BL cancers. Thus it is important to identify potential therapeutic targets and describe their relationship with established prognostic factors. Focal adhesion kinase FAK is upregulated in several human cancers and also plays a functional role in tumour angiogenesis. However, the association between breast cancer sub-types and tumour endothelial-FAK expression is unknown.

MethodsUsing immunofluorescence, we quantified FAK expression in tumour endothelial and tumour cell compartments in 149 invasive breast carcinomas and correlated expression with clinical, pathological and molecular parameters.

ResultsLow endothelial-FAK expression was independently associated with luminal A tumours at univariate p < 0.001 and multivariate p = 0.001 analysis. There was a positive correlation between FAK expression in the vascular and tumour cell compartments Spearman’s correlation co-efficient = 0.394, p < 0.001. Additionally, endothelial and tumour cell FAK expression were significantly increased in TN tumours p = 0.043 and p = 0.033 respectively, in tumours with negative ER and PR status, and in high grade tumours at univariate analysis.

ConclusionOur findings establish a relationship between endothelial-FAK expression levels and the molecular sub-type of invasive breast cancer, and suggest that endothelial-FAK expression is potentially more clinically relevant than tumour cell FAK expression in breast cancer.

KeywordsFAK Endothelium Breast cancer Molecular sub-type Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-237 contains supplementary material, which is available to authorized users.

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Author: Annika N Alexopoulou - Colan M Ho-Yen - Vassilis Papalazarou - George Elia - J Louise Jones - Kairbaan Hodivala-Dilke

Source: https://link.springer.com/







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