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BMC Cancer

, 14:235

Clinical oncology

Abstract

BackgroundAnaplastic thyroid carcinoma ATC is a malignancy with one of the highest fatality rates. We reviewed our recent clinical experience with intensity modulated radiotherapy IMRT combined with surgery and chemotherapy for the management of ATC.

Methods13 patients with ATC who were treated by IMRT in our institution between October 2008 and February 2011, have been analyzed. The target volume for IMRT was planned to include Gross tumor volume GTV: primary tumor plus any N + disease 66 Gy-33 F-6.6 W, with elective irradiation of thyroid bed, bilateral level II through VI and mediastinal lymph nodes to the level of the carina 54-60 Gy. Seven patients received surgical intervention and eleven patients had chemotherapy.

ResultsThe median radiotherapy dose to GTV was 60 Gy-30 fractions-6 weeks. The median survival time of the 13 patients was 9 months. The direct causes of death were distant metastases 75% and progression of the locoregional disease 25%. Ten patients were spared dyspnea and tracheostomy because their primary neck lesion did not progress.

ConclusionThe results showed that IMRT combined by surgery and chemotherapy for ATC might be beneficial to improve locoregional control. Further new therapies are needed to control metastases.

KeywordsAnaplastic thyroid carcinoma ATC Intensity modulated radiotherapy Locoregional control Distant metastases  Download fulltext PDF



Author: Xiayun He - Duanshu Li - Chaosu Hu - Zhuoying Wang - Hongmei Ying - Yi Wu

Source: https://link.springer.com/







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