Association of adiponectin with hepatic steatosis: a study of 1,349 subjects in a random population sampleReport as inadecuate

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BMC Research Notes

, 7:207

First Online: 03 April 2014Received: 30 July 2013Accepted: 31 March 2014DOI: 10.1186-1756-0500-7-207

Cite this article as: Flechtner-Mors, M., George, S.N., Oeztuerk, S. et al. BMC Res Notes 2014 7: 207. doi:10.1186-1756-0500-7-207


BackgroundObjective of the present study was to examine the association between adiponectin and hepatic steatosis, and other biochemical and anthropometric parameters in healthy subjects.

ResultsA total of 1349 subjects age 18–65 years underwent ultrasound examination of the liver. Mean adiponectin concentration for the study collective was 11.35 ± 6.28 μg-mL. The following parameters were assessed for their association with adiponectin: body-mass index BMI; age; sex; arterial blood pressure; nicotine use; alcohol consumption; physical activity; metabolic syndrome; total, low-density lipoprotein LDL and high-density lipoprotein HDL cholesterol; triglycerides; aspartate aminotransferase AST; alanine aminotransferase ALT; γ-glutamyltransferase GGT; alkaline phosphatase AP; C-reactive protein CRP; insulin sensitivity according to the Homeostasis Model Assessment HOMA; random blood glucose; and the degree of steatosis of the liver. The numerical differences in the variables influencing adiponectin returned in the descriptive analysis were confirmed at bivariate analysis for BMI, ALT, AST, GGT, AP, total and HDL cholesterol, triglycerides, CRP, arterial blood pressure, metabolic syndrome, nicotine use and alcohol consumption. The logistic regression of the multivariate analysis showed that male sex, hepatic steatosis, BMI, metabolic syndrome, tobacco smoking and CRP correlate negatively with adiponectin, while age, moderate alcohol consumption and HDL cholesterol exhibit a positive association.

ConclusionsThe results of the present study confirm the findings of previous research. Adiponectin correlates negatively with cardiometabolic risk factors and is an independent indicator for non-alcoholic fatty liver disease NAFLD.

KeywordsUltrasonography Fatty liver NAFLD Adipose tissue Cross-sectional studies AbbreviationsALTAlanine aminotransferase

AMPKActivated protein kinase

APAlkaline phosphatase

ASTAspartate aminotransferase

BMIBody-mass index

CADCoronary artery disease

CRPC-reactive protein


HCCHepatocellular carcinoma

HDLHigh-density lipoprotein

HOMAHomeostatic model assessment

LDLLow-density lipoprotein

MAPKMitogen-activated protein kinase

NAFLNon-alcohol fatty liver

NAFLDNon-alcoholic fatty liver disease

NASHNon-alcoholic steatohepatitis

NCEP-ATP IIINational cholesterol education program adult treatment panel III

PPARPeroxisome proliferator-activated receptor

SDStandard deviation.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-7-207 contains supplementary material, which is available to authorized users.

Marion Flechtner-Mors, Samuel N George contributed equally to this work.

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