The Leeds Evaluation of Efficacy of Detoxification Study LEEDS Prisons Project Study: protocol for a randomised controlled trial comparing methadone and buprenorphine for opiate detoxificationReportar como inadecuado




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Trials

, 10:53

First Online: 14 July 2009Received: 23 February 2009Accepted: 14 July 2009DOI: 10.1186-1745-6215-10-53

Cite this article as: Sheard, L., Wright, N.M., Adams, C.E. et al. Trials 2009 10: 53. doi:10.1186-1745-6215-10-53

Abstract

BackgroundIn the United Kingdom UK, there is an extensive market for the class -A- drug heroin and many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to cease their drug use. The most commonly used detoxification agents in UK prisons are currently buprenorphine and methadone, both are recommended by national clinical guidelines. However, these agents have never been compared for opiate detoxification in the prison estate and there is a general paucity of research evaluating the most effective treatment for opiate detoxification in prisons. This study seeks to address this paucity by evaluating the most routinely used interventions amongst drug users within UK prisons.

Methods-DesignThis study uses randomised controlled trial methodology to compare the open use of buprenorphine and methadone for opiate detoxification, given in the context of routine care, within three UK prisons. Prisoners who are eligible and give informed consent will be entered into the trial. The primary outcome will be abstinence status eight days after detoxification, as determined by a urine test. Secondary outcomes will be recorded during the detoxification and then at one, three and six months post-detoxification.

Trial registrationCurrent Controlled Trials ISRCTN58823759

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Autor: Laura Sheard - Nat MJ Wright - Clive E Adams - Nicole Bound - Bruno Rushforth - Roger Hart - Charlotte NE Tompkins

Fuente: https://link.springer.com/







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