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Journal of Translational Medicine

, 12:88

Cell, tissue and gene therapy

Abstract

Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation property and low production of cartilage-specific extracellular matrix ECM of the chondrocytes, the cartilage synthesis in vitro has been one of the major limitations for obtaining high-quality engineered cartilage constructs. This review discusses cells, biomaterial scaffolds and stimulating factors that can facilitate the cartilage-specific ECM production and accumulation in the in vitro culture system. Special emphasis has been put on the factors that affect the production of ECM macromolecules such as collagen type II and proteoglycans in the review, aiming at providing new strategies to improve the quality of tissue-engineered cartilage.

KeywordsCartilage Tissue engineering Extracellular matrix Collagen type II Electronic supplementary materialThe online version of this article doi:10.1186-1479-5876-12-88 contains supplementary material, which is available to authorized users.

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Author: Jie-Lin Chen - Li Duan - Weimin Zhu - Jianyi Xiong - Daping Wang

Source: https://link.springer.com/







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