Cause-effect relations between 55 kD soluble TNF receptor concentrations and specific and unspecific symptoms in a patient with mild SLE disease activity: an exploratory time series analysis studyReport as inadecuate




Cause-effect relations between 55 kD soluble TNF receptor concentrations and specific and unspecific symptoms in a patient with mild SLE disease activity: an exploratory time series analysis study - Download this document for free, or read online. Document in PDF available to download.

BMC Research Notes

, 8:465

First Online: 21 September 2015Received: 03 November 2013Accepted: 31 August 2015DOI: 10.1186-s13104-015-1398-z

Cite this article as: Schubert, C., Haberkorn, J., Ocaña-Peinado, F.M. et al. BMC Res Notes 2015 8: 465. doi:10.1186-s13104-015-1398-z

Abstract

BackgroundThis integrative single-case study investigated the 12 h-to-12 h cause-effect relations between 55 kD soluble tumor necrosis factor receptor type 1 sTNF-R55 and specific and unspecific symptoms in a 52-year-old Caucasian woman with mild systemic lupus erythematosus SLE disease activity.

MethodsThe patient collected her entire urine for 56 days in 12 h-intervals to determine sTNF-R55-creatinine and protein-creatinine levels ELISA, HPLC. Additionally, twice a day, she took notes on oral ulceration and facial rash; answered questionnaires VAS on fatigue, weakness, and joint pain; and measured body temperature orally. Time series analysis consisted of ARIMA modeling and cross-correlational analyses significance level = p < 0.05.

ResultsTime series analysis revealed both a circadian and a circasemiseptan rhythm in the urinary sTNF-R55 data. Moreover, several significant lagged correlations between urinary sTNF-R55 concentrations and SLE symptoms in both directions of effect were identified. Specifically, increased urinary sTNF-R55 concentrations preceded decreased urinary protein levels by 36–48 h r = −0.213 and, in the opposite direction of effect, increased protein levels preceded increased sTNF-R55 concentrations by 24–36 h r = +0.202. In addition, increased urinary sTNF-R55 levels preceded increased oral ulcers by 36–48 h r = +0.277 and, conversely, increased oral ulceration preceded decreased sTNF-R55 levels by 36–48 h r = −0.313. Moreover, increased urinary sTNF-R55 levels preceded decreased facial rash by 36–48 h r = −0.223 and followed increased body temperature after 36–48 h r = +0.209. Weakness, fatigue and joint pain were not significantly correlated with urinary sTNF-R55 levels.

ConclusionsThis study gathered first evidence of real-life, long-term feedback loops between cytokines and SLE symptoms in mild SLE disease activity. Such insights into the potential role of sTNF-R55 in SLE would not have been possible had we applied a pre-post design group study. These findings require replication before firm conclusions can be drawn.

KeywordssTNF-R55 Lupus Proteinuria Oral ulcer Facial rash Time series analysis ARIMA modeling Cross-correlation Single case study An erratum to this article is available at http:-dx.doi.org-10.1186-s13104-017-2419-x.

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Author: Christian Schubert - Julia Haberkorn - Francisco M. Ocaña-Peinado - Paul König - Norbert Sepp - Mirjam Schnapka-Köpf - D

Source: https://link.springer.com/







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