Synthesis of new 4-nitrosophenyl-1,4-dihydropyridines of pharmacological interestReport as inadecuate




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The synthesis and characterization of a series of 4-nitrosophenyl-1.4-dihydropyridines derived from the respective nitro compounds of pharmacological interest is described. The complete synthetic pathway is based on the classical Hantzsch 1,4-dihydropyridine synthesis to obtain the nitrophenyl 1,4-dihydropyridines in a first step, followed by chemical reduction of the nitro compound to the corresponding hydroxylamine and further oxidation to the nitroso derivative. The synthesis and characterization of the compounds is described.Nota general

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Author: Santander Gutierrez, Ingrid Paola; - Núñez Vergara, Luis; - Squella Serrano, Juan; - Navarrete Encina, Patricio; -

Source: http://repositorio.uchile.cl/



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