Breastfeeding in relation to risk of different breast cancer characteristicsReport as inadecuate

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BMC Research Notes

, 7:216

First Online: 07 April 2014Received: 27 November 2012Accepted: 21 March 2014DOI: 10.1186-1756-0500-7-216

Cite this article as: Butt, S., Borgquist, S., Anagnostaki, L. et al. BMC Res Notes 2014 7: 216. doi:10.1186-1756-0500-7-216


BackgroundThe aim of this present study was to examine duration of breastfeeding in relation to the risk of different subgroups of breast cancer. A prospective cohort, The Malmö Diet and Cancer study, including 14092 parous women, were followed during a mean of 10.2 years and a total of 424 incident breast cancers were diagnosed.

MethodsTumours were classified regarding invasiveness, tumour size, axillary lymph node status, Nottingham grade, tumour proliferation Ki67, HER2, cyclin D1 and p27, WHO histological type and hormone receptor status. Duration of breastfeeding was measured using total time of breastfeeding, categorized in quartiles using the lowest as the reference group <4.0, ≥4.0- < 8.0, ≥8.0- < 13.0 and ≥13.0 months. Average duration of breastfeeding per child and breastfeeding duration of the first child were also used as exposures in separate analyses. Relative risks, with 95% confidence intervals, were obtained using a Cox’s proportional hazards analysis adjusted for potential confounders.

ResultsOverall risk for breast cancer was similar in all quartiles of breastfeeding. No strong results regarding breastfeeding duration and breast cancer subgroups were seen. A few results indicated an association between a relatively long duration of breastfeeding and tumours with high proliferation Ki67 and grade III histological grade.

ConclusionsBreastfeeding duration was not associated with breast cancer risk and no strong results were seen with regard to breast cancer subgroups.

KeywordsBreast cancer risk Breastfeeding Stage Characteristics Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-7-216 contains supplementary material, which is available to authorized users.

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Author: Salma Butt - Signe Borgquist - Lola Anagnostaki - Göran Landberg - Jonas Manjer


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