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BMC Cancer

, 9:225

First Online: 09 July 2009Received: 03 February 2009Accepted: 09 July 2009DOI: 10.1186-1471-2407-9-225

Cite this article as: Rosser, C.J., Gaar, M. & Porvasnik, S. BMC Cancer 2009 9: 225. doi:10.1186-1471-2407-9-225


Radiation therapy continues to be one of the more popular treatment options for localized prostate cancer. One major obstacle to radiation therapy is that there is a limit to the amount of radiation that can be safely delivered to the target organ. Emerging evidence suggests that therapeutic agents targeting specific molecules might be combined with radiation therapy for more effective treatment of tumors. Recent studies suggest that modulation of these molecules by a variety of mechanisms e.g., gene therapy, antisense oligonucleotides, small interfering RNA may enhance the efficacy of radiation therapy by modifying the activity of key cell proliferation and survival pathways such as those controlled by Bcl-2, p53, Akt-PTEN and cyclooxygenase-2. In this article, we summarize the findings of recent investigations of radiosensitizing agents in the treatment of prostate cancer.

List of abbreviationsMOIMultiplicity Of Infection


PTENPhosphatase and tensin

PI3KPhosphatidylinositol 3 kinase

MAP kinasemitogen-activated protein kinases

PKAPKB, PKC: protein kinase A, B and C

RTOGRadiation Therapy Oncology Group

STADshort course of androgen deprivation therapy

LTADlong course of androgen deprivation therapy

eMRIendorectal magnetic resonance imaging eMRI

TVtumor volume


PSAprostate specific antigen

XRTradiation therapy

bNEDbiochemical no evidence of disease

ADTandrogen deprivation therapy

HRhazard rates

CIconfidence interval.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-9-225 contains supplementary material, which is available to authorized users.

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Author: Charles J Rosser - Micah Gaar - Stacy Porvasnik


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