Prevalence and predictors of Lymphogranuloma venereum in a high risk population attending a STD outpatients clinic in ItalyReportar como inadecuado

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BMC Research Notes

, 7:225

First Online: 09 April 2014Received: 28 January 2014Accepted: 04 April 2014DOI: 10.1186-1756-0500-7-225

Cite this article as: Foschi, C., Marangoni, A., D’Antuono, A. et al. BMC Res Notes 2014 7: 225. doi:10.1186-1756-0500-7-225


BackgroundWe evaluated LGV prevalence and predictors in a high risk population attending a STI Outpatients Clinic in the North of Italy.

MethodsA total of 108 patients 99 MSM and 9 women, with a history of unsafe anal sexual intercourses, were enrolled. Anorectal swabs and urine samples were tested for Chlamydia trachomatis CT DNA detection by Versant CT-GC DNA 1.0 Assay Siemens Healthcare Diagnostics Terrytown, USA. RFLP analysis was used for CT molecular typing.

ResultsL2 CT genotype was identified in 13-108 12% rectal swabs. All LGV cases were from MSM, declaring high-risk sexual behaviour and complaining anorectal symptoms. Patients first attending the STI Outpatient Clinic received a significant earlier LGV diagnosis than those first seeking care from general practitioners or gastroenterologists P = 0.0046.

LGV prevalence and characteristics found in our population are in agreement with international reports. Statistical analysis showed that LGV positive patients were older P = 0.0008 and presented more STIs P = 0.0023 than LGV negative ones, in particular due to syphilis P < 0.001, HIV P < 0.001 and HBV P = 0.001.

Multivariate logistic regression analysis revealed that HIV and syphilis infections are strong risk factors for LGV presence respectively, P = 0.001 and P = 0.010.

ConclusionsEven if our results do not provide sufficient evidence to recommend routine screening of anorectal swabs in high-risk population, they strongly suggest to perform CT NAAT tests and genotyping on rectal specimens in presence of ulcerative proctitis in HIV and-or syphilis-positive MSM. In this context, CT DNA detection by Versant CT-GC DNA 1.0 Assay, followed by RFLP analysis for molecular typing demonstrated to be an excellent diagnostic algorithm for LGV identification.

KeywordsLGV MSM Chlamydia trachomatis NAATs Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-7-225 contains supplementary material, which is available to authorized users.

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Autor: Claudio Foschi - Antonella Marangoni - Antonietta D’Antuono - Paola Nardini - Monica Compri - Sara Bellavista - Andrea Fi


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