Preliminary investigation of plasma levels of sex hormones and human growth factors, and P300 latency as correlates to cognitive decline as a function of genderReportar como inadecuado




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BMC Research Notes

, 2:126

First Online: 07 July 2009Received: 17 August 2008Accepted: 07 July 2009DOI: 10.1186-1756-0500-2-126

Cite this article as: Braverman, E.R., Chen, T.J., Chen, A.L. et al. BMC Res Notes 2009 2: 126. doi:10.1186-1756-0500-2-126

Abstract

BackgroundAging is marked by declines in levels of many sex hormones and growth factors, as well as in cognitive function. The P300 event-related potential has been established as a predictor of cognitive decline. We decided to determine if this measure, as well as 2 standard tests of memory and attention, may be correlated with serum levels of sex hormones and growth factors, and if there are any generalizations that could be made based on these parameters and the aging process.

FindingsIn this large clinically based preliminary study several sex-stratified associations between hormone levels and cognition were observed, including 1 for males aged 30 to 49, both IGF-1 and IGFBP-3 significantly associated negatively with prolonged P300 latency; 2 for males aged 30 to 49, the spearman correlation between prolonged P300 latency and low free testosterone was significant; 3 for males aged 60 to 69, there was a significant negative correlation between P300 latency and DHEA levels; 4 for females aged 50 to 59 IGFBP-3 significantly associated negatively with prolonged P300 latency; 5 for females at all age periods, estrogen and progesterone were uncorrelated with P300 latency; and 6 for females aged 40 to 69, there was significant negative correlation between DHEA levels and P300 latency. Moreover there were no statistically significant correlations between any hormone and Wechsler Memory Scale-III WMS-111. However, in females, there was a significant positive correlation between estrogen levels and the number of Attention Deficit Disorder ADD complaints.

ConclusionGiven certain caveats including confounding factors involving psychiatric and other chronic diseases as well as medications, the results may still have important value. If these results could be confirmed in a more rigorously controlled investigation, it may have important value in the diagnosis, prevention and treatment of cognitive impairments and decline.

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Autor: Eric R Braverman - Thomas JH Chen - Amanda LC Chen - Mallory M Kerner - Howard Tung - Roger L Waite - John Schoolfield

Fuente: https://link.springer.com/







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