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Theoretical Biology and Medical Modelling

, 11:16

Mathematical modelling


A brief overview is provided of cosinor-based techniques for the analysis of time series in chronobiology. Conceived as a regression problem, the method is applicable to non-equidistant data, a major advantage. Another dividend is the feasibility of deriving confidence intervals for parameters of rhythmic components of known periods, readily drawn from the least squares procedure, stressing the importance of prior external information. Originally developed for the analysis of short and sparse data series, the extended cosinor has been further developed for the analysis of long time series, focusing both on rhythm detection and parameter estimation. Attention is given to the assumptions underlying the use of the cosinor and ways to determine whether they are satisfied. In particular, ways of dealing with non-stationary data are presented. Examples illustrate the use of the different cosinor-based methods, extending their application from the study of circadian rhythms to the mapping of broad time structures chronomes.

KeywordsChronobiology Chronome Circadian Cosinor External information Regression Rhythm parameters Stationarity Electronic supplementary materialThe online version of this article doi:10.1186-1742-4682-11-16 contains supplementary material, which is available to authorized users.

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Author: Germaine Cornelissen


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