Space-time clusters of breast cancer using residential histories: A Danish case–control studyReport as inadecuate




Space-time clusters of breast cancer using residential histories: A Danish case–control study - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 14:255

Epidemiology, prevention and public health

Abstract

BackgroundA large proportion of breast cancer cases are thought related to environmental factors. Identification of specific geographical areas with high risk clusters may give clues to potential environmental risk factors. The aim of this study was to investigate whether clusters of breast cancer existed in space and time in Denmark, using 33 years of residential histories.

MethodsWe conducted a population-based case–control study of 3138 female cases from the Danish Cancer Registry, diagnosed with breast cancer in 2003 and two independent control groups of 3138 women each, randomly selected from the Civil Registration System. Residential addresses of cases and controls from 1971 to 2003 were collected from the Civil Registration System and geo-coded. Q-statistics were used to identify space-time clusters of breast cancer. All analyses were carried out with both control groups, and for 66% of the study population we also conducted analyses adjusted for individual reproductive factors and area-level socioeconomic indicators.

ResultsIn the crude analyses a cluster in the northern suburbs of Copenhagen was consistently found throughout the study period 1971–2003 with both control groups. When analyses were adjusted for individual reproductive factors and area-level socioeconomic indicators, the cluster area became smaller and less evident.

ConclusionsThe breast cancer cluster area that persisted after adjustment might be explained by factors that were not accounted for such as alcohol consumption and use of hormone replacement therapy. However, we cannot exclude environmental pollutants as a contributing cause, but no pollutants specific to this area seem obvious.

KeywordsSpace-time cluster analysis Breast cancer Residential histories Q-statistics Denmark AbbreviationsHRTHormone replacement therapy

CGControl group.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-255 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Rikke Baastrup Nordsborg - Jaymie R Meliker - Annette Kjær Ersbøll - Geoffrey M Jacquez - Aslak Harbo Poulsen - Ole R

Source: https://link.springer.com/







Related documents