MicroRNAs in urine are not biomarkers of multiple myelomaReport as inadecuate




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Journal of Negative Results in BioMedicine

, 14:16

First Online: 23 September 2015Received: 03 June 2015Accepted: 15 September 2015DOI: 10.1186-s12952-015-0035-7

Cite this article as: Sedlaříková, L., Bešše, L., Novosadová, S. et al. J Negat Results BioMed 2015 14: 16. doi:10.1186-s12952-015-0035-7

Abstract

BackgroundIn this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease.

ResultsAnalysis of urine samples was performed using Serum-Plasma Focus PCR MicroRNA Panel Exiqon and verified using individual TaqMan miRNA assays for qPCR. We found 20 deregulated microRNA p < 0.05; for further validation, we chose 8 of them. Nevertheless, only differences in expression levels of miR-22-3p remained close to statistical significance.

ConclusionsOur preliminary results did not confirm urine microRNA as a potential biomarker for multiple myeloma.

AbbreviationsBMbone marrow

DNdiabetic nephropathy

HDhealthy donors

miRNAsmicroRNAs

MGUSmonoclonal gammopathy of undetermined significance

MMmultiple myeloma

PCsplasma cells

RCCrenal cell carcinoma

UCurothelial carcinoma

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Author: Lenka Sedlaříková - Lenka Bešše - Soňa Novosadová - Veronika Kubaczková - Lenka Radová - Michal Staník - Marta Kr

Source: https://link.springer.com/







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