An accurate and affordable test for the rapid diagnosis of sickle cell disease could revolutionize the outlook for affected children born in resource-limited settingsReportar como inadecuado




An accurate and affordable test for the rapid diagnosis of sickle cell disease could revolutionize the outlook for affected children born in resource-limited settings - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Medicine

, 13:238

First Online: 23 September 2015Received: 07 September 2015Accepted: 08 September 2015DOI: 10.1186-s12916-015-0483-4

Cite this article as: Williams, T.N. BMC Med 2015 13: 238. doi:10.1186-s12916-015-0483-4

Abstract

Each year, at least 280,000 children are born with sickle cell disease SCD in resource-limited settings. For cost, logistic and political reasons, the availability of SCD testing is limited in such settings and consequently 50–90 % of affected children die undiagnosed before their fifth birthday. The recent development of a point of care method for the diagnosis of SCD – the Sickle SCAN™ device – could afford such children the prompt access to appropriate services that has transformed the outlook for affected children in resource-rich areas. In research published in BMC Medicine, Kanter and colleagues describe a small but carefully conducted study involving 208 children and adults, in which they found that by using Sickle SCAN™ it was possible to diagnose the common forms of SCD with 99 % sensitivity and 99 % specificity, in under 5 minutes. If repeatable both in newborn babies and under real-life conditions, and if marketed at an affordable price, Sickle SCAN™ could revolutionize the survival prospects for children born with SCD in resource-limited areas.

Please see related article: http:-dx.doi.org-10.1186-s12916-015-0473-6.

KeywordsSickle cell disease Point of care Diagnostic test AbbreviationsHPLCHigh performance liquid chromatography

PCRPolymerase chain reaction

SCDSickle cell disease

SSASub-Saharan Africa

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Autor: Thomas N. Williams

Fuente: https://link.springer.com/







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