The impact of avoiding cardiopulmonary by-pass during coronary artery bypass surgery in elderly patients: the Danish On-pump Off-pump Randomisation Study DOORSReport as inadecuate




The impact of avoiding cardiopulmonary by-pass during coronary artery bypass surgery in elderly patients: the Danish On-pump Off-pump Randomisation Study DOORS - Download this document for free, or read online. Document in PDF available to download.

Trials

, 10:47

First Online: 04 July 2009Received: 26 January 2009Accepted: 04 July 2009DOI: 10.1186-1745-6215-10-47

Cite this article as: Houlind, K., Kjeldsen, B.J., Madsen, S.N. et al. Trials 2009 10: 47. doi:10.1186-1745-6215-10-47

Abstract

BackgroundCoronary Artery Bypass Graft operation for ischemic heart disease provides improved quality of life and, in some patients, prolonged survival. Concern has, however, been raised about complications that may be related to the use of cardiopulmonary by-pass CPB and aortic cross-clamping. It has been hypothesized that when coronary artery by-pass grafting is performed without the use of CPB, the rate of serious complications is reduced.

Methods-DesignThe trial is designed as an open, randomized, controlled, clinical trial with blinded assessment of end-points. Patients at or above 70 years of age, referred for surgical myocardial revascularisation, are included and randomised to receive coronary artery by-pass grafting either with or without the use of CPB and aortic cross-clamping. Follow-up is performed by clinical, biochemical, electrocardiographic, and angiographic data that are evaluated by independent committees that are blinded with respect to the result of the randomisation. End points include mortality, stroke, myocardial infarction, graft patency, quality of life, and cost-effectiveness. The trial is performed in four different Danish, cardiac surgery centres.

Trial registrationClinicalTrials.gov NCT00123981

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Author: Kim Houlind - Bo Juul Kjeldsen - Susanne Nørgaard Madsen - Bodil Steen Rasmussen - Susanne Juel Holme - Thomas Andersen

Source: https://link.springer.com/







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