The effects of iodine blocking following nuclear accidents on thyroid cancer, hypothyroidism, and benign thyroid nodules: design of a systematic reviewReportar como inadecuado




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Systematic Reviews

, 4:126

First Online: 24 September 2015Received: 20 July 2015Accepted: 26 August 2015DOI: 10.1186-s13643-015-0106-3

Cite this article as: Dreger, S., Pfinder, M., Christianson, L. et al. Syst Rev 2015 4: 126. doi:10.1186-s13643-015-0106-3

Abstract

BackgroundOne of the most efficient radiation protection methods to reduce the risk of adverse health outcomes in case of accidental radioactive iodine release is the administration of potassium iodine KI. Although KI administration is recommended by WHO’s guidelines for iodine prophylaxis following nuclear accidents and is also widely implemented in most national guidelines, the scientific evidence for the guidelines lacks as the guidelines are mostly based on expert opinions and recommendations. Therefore, this study will provide evidence by systematically reviewing the effects of KI administration in case of accidental radioactive iodine release on thyroid cancer, hypothyroidism, and benign nodules.

MethodsWe will apply standard systematic review methodology for the identification of eligible studies, data extraction, assessment of risk of biases, heterogeneity, and data synthesis. The electronic database search will be conducted in MEDLINE via PubMed and EMBASE, and covers three search blocks with terms related to the health condition, intervention, and occurrence-location. We have no date or language restrictions, but restrictions to humans only. We will include studies comparing the effects of KI administration on thyroid cancer, hypothyroidism, and benign thyroid nodules in a population exposed to radioactive iodine release. The quality of the studies will be graded. If feasible, a meta-analysis will be conducted.

DiscussionThis proposed systematic review will update the existing WHO guideline from 1999. New evidence on the efficacy of KI administration to reduce thyroid cancer, hypothyroidism, and benign thyroid nodules in the event of an accidental release of radioactive iodine to the environment will provide the basis for an update of the WHO guideline for iodine prophylaxis following nuclear accidents.

Systematic review registrationPROSPERO CRD42015024340

KeywordsStable oral iodine Potassium iodine Chernobyl Health outcomes I-131 Reactor accident AbbreviationsCPHGCochrane Public Health Group

EMBASEExcerpta Medica Database

EPOCEffective Practice and Organisation of Care

HRhazard ratio

ITSinterrupted time series

MDmean difference

ORodds ratio

RDrisk difference

RRrisk ratio

RCTrandomized clinical trial

WHOWorld Health Organization

Steffen Dreger and Manuela Pfinder are co-first authors.

Steffen Dreger and Manuela Pfinder contributed equally to this work.

Electronic supplementary materialThe online version of this article doi:10.1186-s13643-015-0106-3 contains supplementary material, which is available to authorized users.

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Autor: Steffen Dreger - Manuela Pfinder - Lara Christianson - Stefan K Lhachimi - Hajo Zeeb

Fuente: https://link.springer.com/







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