Seroprevalence and transmission of Hepatitis B virus among delivering women and their new born in selected health facilities, Addis Ababa, Ethiopia: a cross sectional studyReportar como inadecuado

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BMC Research Notes

, 7:239

First Online: 15 April 2014Received: 21 October 2013Accepted: 11 April 2014DOI: 10.1186-1756-0500-7-239

Cite this article as: Tegegne, D., Desta, K., Tegbaru, B. et al. BMC Res Notes 2014 7: 239. doi:10.1186-1756-0500-7-239


BackgroundHepatitis B Virus is a major public health problem worldwide. In 2012 alone, over 350 million chronic carriers and 1. 2 million annual deaths were occurred. Hepatitis B Virus causes 60 to 80% of the world’s primary liver cancer and nearly 90% infants infected due to vertical transmission are at higher risk of developing chronic liver disease and cancer. Hence determining the burden of maternal and neonatal Hepatitis B Virus infection is a priority.

MethodsA cross sectional study was conducted from July – September 2012 at St. Paul’s Hospital Millennium Medical College and Selam Health Center, Addis Ababa, Ethiopia. Blood samples from delivering mothers n = 265 and their corresponding cords n = 265 were collected. A pretested questionnaire was used to collect data. Hepatitis B Virus surface antigen was detected using Enzyme Linked Immunosorbent Assay. Frequency analysis and logistic regression test was used to identify the potential risk factors associated with Hepatitis B Virus positivity using SPSS Version -15.

ResultsA total of 265 delivering women with the mean age of 25.8 years were enrolled in the study. Of these delivering women, 8 3.0% of mothers were positive for Hepatitis B Virus surface antigen, whereas 6 2.3% of cord bloods were positives with 75% concordance rate of exposed infants with sero-positive mothers. However, only one maternal positive case was observed for Hepatitis B e Ag test. Only 11% of the mothers know their Hepatitis B Virus status. Of the total mothers assessed for possible risk factors, 69 26% had only one type, while 161 60.8% had multiple exposure factors such as ear pricing, history of tribal marks, abortion, multiple-sexual partner and history of surgical procedures experienced from high to low frequency. The remaining 35 13.2% of the participants had not experienced possible risk factors.

ConclusionThough the maternal positivity rate was low, the rate of positivity in cord bloods was almost equal to those infected mothers. Therefore, screening of pregnant mothers and vaccination of infants could help to reduce the transmission. To minimize the higher overall risk exposure status of mothers, increasing awareness and intensive public health education is also recommended.

KeywordsHepatitis B virus Seroprevalence Risk factor Delivering women Cord blood AbbreviationsANCAnti natal care

CDCCenters for disease control and prevention

ELISAEnzyme linked immuno sorbent assay

HBeAgHepatitis B e Antigen

HBsAgHepatitis B surface Antigen

HBVHepatitis B virus

HCCHepatocellular carcinoma

HCVHepatitis C virus

HIVHuman immunodeficiency virus

SOPsStandard operating procedures

SPSSStatistical package for the social sciences

WHOWorld Health Organization.

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Autor: Dessie Tegegne - Kassu Desta - Belete Tegbaru - Tesfaye Tilahun


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