The muscle mass, omega-3, diet, exercise and lifestyle MODEL study – a randomised controlled trial for women who have completed breast cancer treatmentReport as inadecuate




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BMC Cancer

, 14:264

Epidemiology, prevention and public health

Abstract

BackgroundLoss of lean body mass LBM is a common occurrence after treatment for breast cancer and is related to deleterious metabolic health outcomes Clin Oncol, 22 4:281–288, 2010; Appl Physiol Nutr Metab, 34 5:950–956, 2009. The aim of this research is to determine the effectiveness of long chain omega-3 fatty acids LCn-3s and exercise training alone, or in combination, in addressing LBM loss in breast cancer survivors.

Methods-designA total of 153 women who have completed treatment for breast cancer in the last 12 months, with a Body Mass Index BMI of 20 to 35 kg-m, will be randomly assigned to one of 3 groups: 3g-d LCn-3s N-3, a 12-week nutrition and exercise education program plus olive oil P-LC or the education program plus LCn-3s EX+N-3. Participants randomised to the education groups will be blinded to treatment, and will receive either olive oil placebo OO+N-3 or LCn-3 provision, while the N-3 group will be open label. The education program includes nine 60-75min sessions over 12 weeks that will involve breast cancer specific healthy eating advice, plus a supervised exercise session run as a resistance exercise circuit. They will also be advised to conduct the resistance training and aerobic training 5 to 7 days per week collectively. Outcome measures will be taken at baseline, 12-weeks and 24-weeks. The primary outcome is % change in LBM as measured by the air displacement plethysmograhy. Secondary outcomes include quality of life FACT-B + 4 and inflammation C-Reactive protein: CRP. Additional measures taken will be erythrocyte fatty acid analysis, fatigue, physical activity, menopausal symptoms, dietary intake, joint pain and function indices.

DiscussionThis research will provide the first insight into the efficacy of LCn-3s alone or in combination with exercise in breast cancer survivors with regards to LBM and quality of life. In addition, this study is designed to improve evidence-based dietetic practice, and how specific dietary prescription may link with appropriate exercise interventions.

Trials registrationACTRN12610001005044; and World Health Organisation Universal trial number: U1111-1116-8520.

KeywordsBreast cancer Omega-3 fatty acids Body composition Exercise Lean body mass Inflammation AbbreviationsADPAir displacement plethysmography

BMIBody mass index

CT-scanComputed tomography

DemoDemographics

DEXADual-energy X-ray absorptiometry

E-LCEducation program plus LCn-3s

FACT-B + 4Functional assessment cancer therapy – breast +4 items

Hs-CRPHigh sensitivity C-reactive protein

LBMLean body mass

LC3g-d LCn-3s alone

LCn-3 FAsLong chain omega-3 fatty acids

MRIMagnetic resonance imaging

P-LC12-week nutrition and exercise education program plus olive oil group

QOLQuality of life.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-264 contains supplementary material, which is available to authorized users.

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Author: Cameron McDonald - Judy Bauer - Sandra Capra - Joseph Coll

Source: https://link.springer.com/







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