Experimental studies on the effect of Lambda-Cyhalothrin insecticide on lungs and the ameliorating effect of plant extracts Ginseng Panax Ginseng and garlic Allium sativum L. on asthma development in albino ratsReportar como inadecuado




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BMC Research Notes

, 7:243

First Online: 16 April 2014Received: 05 September 2013Accepted: 11 April 2014DOI: 10.1186-1756-0500-7-243

Cite this article as: Mohi El-Din, M.M., Mostafa, A.M. & Abd-Elkader, A. BMC Res Notes 2014 7: 243. doi:10.1186-1756-0500-7-243

Abstract

BackgroundLambda-cyhalothrin LTC is a synthetic pyrethroid insecticide for agricultural and public health applications. This study was to determine the pathological alterations of LTC in lungs, which has not previously been studied, and the ameliorating effects of plant extracts ginseng and garlic on the development of asthma in albino rats.

MethodsFour groups gps of albino rats, n = 20, average body weight = 200 gm with an age of 4 months, were formed. Gp 1 was kept as control. Gp 2 was injected intraperitoneally i.p. with LTC at a dose of 1-6 LD50 that is 9.34 mg-kg body weight w.t. daily for 21 days d. Gp 3 and 4 were injected i.p. with ginseng at the dose of 200 mg-kg b.wt and garlic Allium sativum L. at the dose of 100 mg-kg b.wt., respectively, one hour before being given LTC at a dose of 1-6 LD50 9.34 mg-kg b.wt. daily. Each groups were divided into two sacrificed, at 15 and 21 d p.i. Blood and lung samples were collected for hematological and histopathological examinations.

ResultsHematological findings showed that the animals in gps 2 and 3, which were treated for 21 days, showed a significant difference in RBC counts P > .001, Hb P > .007, PCV% P > .004, P > .008 in comparison with the control group. Signs of cough and nasal discharge were seen in gp 2, which became mild in gp 4. Grossly, the lungs showed congestion and consolidation in gp 2. Histopathologically, macroabscesses and interstitial alveolitis were seen in gp 2, which led to obstruction in the lumen of the bronchioles at 21 d p.i. Meanwhile, thickening in the interalveolar septa with mononuclear cells was seen in gps. 3 and 4 at 21d p.i.

ConclusionsThe study shows 3 gps of rats injected with LHC alone or combined with garlic and ginseng extract, each group were divided into two sacrificed 15 and 21 d p.i

Lambda cyhalothrin causes bronchial obstruction in the lungs of the rats 15 and 21 d p.i, which decreased into mild to moderate interstitial inflammation in the rats given garlic and ginseng, respectively.

KeywordsAlbino rats Airway inflammation Asthma LTC Garlic Ginseng plants Pathology AbbreviationsLTCLambda cyhalothrin

i.pIntraperitoneally.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-7-243 contains supplementary material, which is available to authorized users.

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Autor: Mouchira M Mohi El-Din - Amna M Mostafa - Aml Abd-Elkader

Fuente: https://link.springer.com/







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