Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells featuresReportar como inadecuado

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BMC Cancer

, 14:262

Clinical oncology


BackgroundExtraneural metastases ENM rarely occur in medulloblastoma MBL patients and only few cases of subcutaneous localizations have been described. ENM indicate an aggressive disease associated with a worse prognosis. The characterization of metastatic tumours might be useful to understand their pathogenesis and to identify the most appropriate therapeutic strategies.

Case presentationWe present the case of a child with Large Cell Anaplastic LC-A MBL, who developed multiple subcutaneous metastases in the scalp area after a ventriculo-peritoneal shunting procedure. The disease rapidly progressed and the child died despite chemotherapy and primary tumour surgical debulking.

We molecularly classified the tumour as a group 3 MBL; in addition, we derived stem-like cells SLC from a metastatic lesion. Primary tumour, metastases and SLC were further analysed, particularly focusing on features linked to the cutaneous dissemination. Indeed, molecules involved in angiogenesis, cell invasion and epidermal growth factor signalling resulted highly expressed.

ConclusionsThe present report describes a very rare case of subcutaneous metastatic MBL. The tumour, metastases and SLC have been clinically, pathologically and molecularly characterized. Our case is an example of multidisciplinary approach aiming to characterize MBL aggressive behaviour.

KeywordsMedulloblastoma Stem-like cells Molecular features Subcutaneous metastasis Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-262 contains supplementary material, which is available to authorized users.

Angela Mastronuzzi, Evelina Miele contributed equally to this work.

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Autor: Angela Mastronuzzi - Evelina Miele - Agnese Po - Manila Antonelli - Francesca Romana Buttarelli - Giovanna Stefania Colafa


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