Use of inhaled corticosteroids for the prevention and-or treatment of bronchopulmonary dysplasia in preterm infants: a systematic review protocolReportar como inadecuado




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Systematic Reviews

, 4:127

First Online: 25 September 2015Received: 06 July 2015Accepted: 04 September 2015DOI: 10.1186-s13643-015-0108-1

Cite this article as: Shinwell, E.S., Portnov, I., Meerpohl, J. et al. Syst Rev 2015 4: 127. doi:10.1186-s13643-015-0108-1

Abstract

BackgroundInhaled steroids have been studied for both prevention and treatment of bronchopulmonary dysplasia BPD. Results have been inconsistent. Recently, a large randomized controlled trial RCT has been reported.

Methods-designWe will perform a comprehensive systematic literature search for randomized and quasi-randomized controlled trials that studied the efficacy and safety of inhaled corticosteroids administered to preterm infants 22–36 weeks for either the prevention or treatment of BPD diagnosed by both clinical and physiological outcome criteria. We will assess potential risk of bias for each RCT meeting our selection criteria using the Cochrane risk of bias tool for RCTs. The primary outcome of interest will be mortality or BPD or both at 28 days postnatal age or 36 weeks postmenstrual age. Pooled estimates will be calculated using RevMan software with a random effects model as primary analysis. We will assess the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation GRADE approach.

DiscussionMeta-analytic estimates of eligible RCTs, potentially including a new large RCT, may significantly influence neonatal practice in the prevention and treatment of respiratory problems in preterm infants.

Systematic review registrationPROSPEROCRD42015019628

KeywordsPreterm infant Bronchopulmonary dysplasia Inhaled corticosteroids Corticosteroids Prevention AbbreviationsBPDbronchopulmonary dysplasia

ELBWextremely low birth weight

IVHintraventricular hemorrhage

PMApostmenstrual age

PNApostnatal age

PRISMAPreferred Reporting Items for Systematic Reviews and Meta-Analyses

RCTrandomized controlled trial

ROPretinopathy of prematurity

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Autor: Eric S. Shinwell - Igor Portnov - Joerg Meerpohl - Tanja Karen - Dirk Bassler

Fuente: https://link.springer.com/



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