Disposition kinetics of dibekacin in normal subjects and in patients with renal failureReport as inadecuate

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Dibekacin pharmacokinetics was studied in ten healthy volunteers and six patients with renal failure presenting Clcr<10ml.min-1 per 1.73m2 of body surface, given as a low intravenous bolus to the volunteers and as 30-minute intravenous infusion to the patients. The antibiotic was assayed in plasma and urine by means of a microbiological method using Bacillus subtilis. A two-compartment kinetic model was used to describe the bi-phasic decline of the plasma concentration thus establishing the different pharmacokinetic parameters. Elimination parameters β, k10 = 0.016 min-1 and Cl = 0.87 ml.min-1 kg body weight in normal subjects and t1-2β = 21.4 h, k10 = 0.0011 min-1 and Cl = 0.131 ml.min-1 per kg in the patients. Other kinetic parameters, as distribution α and transfer k12,k21 constants were lower in patients than in volunteers. Also the different terms of volume of distribution of the two-compartment model V1, Vdss, Vdarea were significantly higher in patient than in normal subjects p<0.05. A good correlation r = 0.955. Urinary recovery at 24 h was 89.0% of the dose given to normals and 15.8% of the dose given to patients.

Author: Arancibia, Aquiles; - Chávez Arrué, Jorge; - Ibarra, R.; - Ruiz, I.; - Icarte, A.; - Thambo Becker, Sergio; - Chávez, H.; -

Source: http://repositorio.uchile.cl/


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