Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses Health StudyReportar como inadecuado

Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses Health Study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cancer

, 9:172

First Online: 06 June 2009Received: 05 December 2008Accepted: 06 June 2009DOI: 10.1186-1471-2407-9-172

Cite this article as: Nan, H., Qureshi, A.A., Hunter, D.J. et al. BMC Cancer 2009 9: 172. doi:10.1186-1471-2407-9-172


BackgroundThe human fibroblast growth factor FGF and its receptor FGFR play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers.

MethodsWe evaluated the associations of four genetic variants in the FGFR2 gene highly related to breast cancer risk and the three common tag-SNPs in the FGFR4 gene with skin cancer risk in a nested case-control study of Caucasians within the Nurses- Health Study NHS among 218 melanoma cases, 285 squamous cell carcinoma SCC cases, 300 basal cell carcinoma BCC cases, and 870 controls.

ResultsWe found no evidence for associations between these seven genetic variants and the risks of melanoma and nonmelanocytic skin cancer.

ConclusionGiven the power of this study, we did not detect any contribution of genetic variants in the FGFR2 or FGFR4 genes to inherited predisposition to skin cancer among Caucasian women.

List of AbbreviationsFGFR Fibroblast Growth Factor Receptor

BCC Basal Cell Carcinoma

SCC Squamous Cell Carcinoma

OR Odds Ratio

CI Confidence Interval

UV Ultraviolet.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-9-172 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Autor: Hongmei Nan - Abrar A Qureshi - David J Hunter - Jiali Han


Documentos relacionados