Clinical implications of SPRR1A expression in diffuse large B-cell lymphomas: a prospective, observational studyReport as inadecuate

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BMC Cancer

, 14:333

Translational oncology


BackgroundCertain markers have been identified over the last 10 years that facilitate the prediction of a patient’s prognosis; these markers have been proposed to be useful for risk stratification of lymphoma patients and for the development of specific therapeutic strategies. In the present study, we assessed the potential prognostic value of SPRR1A expression in 967 patients with diffuse large B-cell lymphomas.

MethodsAll patients were enrolled between 2001 and 2007 median follow-up, 53.3 months in the Second Hospital of Dalian Medical University, First Hospital of China Medical University, and Liaoning Cancer Hospital. Immunohistochemical analysis was used to evaluate the expression of SPRR1A. Survival was analyzed using the Kaplan–Meier method. Multivariate analysis was conducted to adjust the effect of SPRR1A expression for potential, well-known, independent prognostic factors.

ResultsOf the 967 patients examined, SPRR1A expression was detected in 305 31.54% patients on immunohistochemical analysis. The 5-year survival rate was significantly lower in patients with SPRR1A expression than in those without 26.9% vs. 53.2%, P < 0.001. Multivariate analysis identified SPRR1A expression as an independent predictor of survival in addition to lactate dehydrogenase level, clinical stage, and histologic subtype.

ConclusionsSPRR1A expression may be useful as a prognostic factor for diffuse large B-cell lymphoma.

KeywordsDiffuse large B-cell lymphomas Survival SPRR1A AbbreviationsBMBone marrow

CRComplete remission

DLBCLDiffuse large B-cell lymphoma

HLAHuman leukocyte antigen

SPRRSmall protein-rich

PBSPhosphate buffered saline

GCBGerminal center B-cell.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-333 contains supplementary material, which is available to authorized users.

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Author: Hao Zhang - Jiyue Gao - Zuowei Zhao - Man Li - Caigang Liu


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