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Asthma Research and Practice

, 1:10

First Online: 20 October 2015Received: 13 March 2015Accepted: 24 September 2015DOI: 10.1186-s40733-015-0012-4

Cite this article as: Marques, C.R., Costa, R.S., Costa, G.N

O. et al. asthma res and pract 2015 1: 10. doi:10.1186-s40733-015-0012-4


Multiple factors interact to trigger allergic diseases, including individual genetic background and factors related to the environment such as exposure to allergens, air pollution and respiratory infections. The FOXP3 transcription factor is constitutively expressed in CD4CD25FOXP3 regulatory T cells Tregs and is critical for the maintenance of immune homeostasis. For example, FOXP3 is responsible for the suppression of the Th2 response following exposure to allergens. Studies have shown that expression of the FOXP3 gene is reduced in patients with asthma and allergies compared to healthy controls. Therefore, the impairment of FOXP3 function caused by genetic polymorphisms and-or epigenetic mechanisms may be involved in the etiology of asthma and other allergic diseases. This review discusses some aspects of the role of FOXP3 in the development of asthma and allergy, with a particular emphasis on genetic and epigenetic factors.

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Autor: Cintia Rodrigues Marques - Ryan Santos Costa - Gustavo Nunes de Oliveira Costa - Thiago Magalhães da Silva - Tatiane O


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