Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin IIReportar como inadecuado




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Resumen

The Angiotensin II Ang II type 1 AT1R and type 2 AT2R receptors are increased in the heart following myocardial infarction and dilated cardiomyopathy, yet their contribution at a cellular level to compensation and-or failure remains controversial.METHODSWe ectopically expressed AT1R and AT2R in cultured adult rat cardiomyocytes and cardiac fibroblasts to investigate Ang II-mediated cardiomyocyte hypertrophy and cardiac cell viability.RESULTSIn adult rat cardiomyocytes, Ang II did not induce hypertrophy via the AT1R, and no effect of Ang II on cell viability was observed following AT1R or AT2R expression. In adult rat cardiac fibroblasts, Ang II stimulated cell death by apoptosis via the AT1R but not the AT2R, which required the presence of extracellular calcium, and induced a rapid dissipation of mitochondrial membrane potential, which was significant from 8 h.CONCLUSIONSWe conclude that Ang II-AT1R triggers apoptosis in adult rat cardiac fibroblasts, which is dependent on Ca2+ influx.



Autor: Aránguiz Urroz, Pablo Daniel; - Soto Muñoz, Dagoberto; - Contreras Ferrat, Ariel Eduardo; - Troncoso Cotal, Rodrigo Andrés; -

Fuente: http://repositorio.uchile.cl/



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