Gln27-> Glu beta2-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to CarvedilolReportar como inadecuado




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Resumen

We investigated the clinical response of chronic heart failure patients with beta2- adrenergic receptor Gln27-> Glu polymorphism treated for 6 months with carvedilol, a alpha-beta-antagonist with antioxidant properties. The 6-min. walk test, the left ventricular ejection fraction, heart rate, plasma norepinephrine and malondialdehyde, a stress oxidative marker, concentrations were evaluated at baseline and after treatment for 6 months with carvedilol in 33 stable chronic heart failure patients with the Gln27-> Glu beta2-adrenergic receptor polymorphism. Carvedilol significantly increased the left ventricular ejection fraction, while decreasing the heart rate and malondialdehyde plasma concentrations in chronic heart failure patients with the Glu27->beta2-adrenergic receptor allele. There were however, no significant changes in patients with the Gln27->beta2-adrenergic receptor variant.



Autor: Troncoso Cotal, Rodrigo Andrés; - Moraga, Francisco; - Chiong Lay, Mario; - Roldán S., Juan; - Bravo Méndez, Roberto; - Valenz

Fuente: http://repositorio.uchile.cl/



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