Biomarkers of oxidant stress, insulin sensitivity and endothelial activation in rheumatoid arthritis: a cross-sectional study of their association with accelerated atherosclerosisReportar como inadecuado




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BMC Research Notes

, 2:83

First Online: 09 May 2009Received: 24 November 2008Accepted: 09 May 2009DOI: 10.1186-1756-0500-2-83

Cite this article as: Pemberton, P.W., Ahmad, Y., Bodill, H. et al. BMC Res Notes 2009 2: 83. doi:10.1186-1756-0500-2-83

Abstract

BackgroundWomen with rheumatoid arthritis RA have increased morbidity and mortality due to coronary heart disease. Chronic systemic inflammation is known to accelerate atherosclerosis and increase arterial stiffness in patients, but other mechanisms may also be involved. Biomarkers of oxidant stress, inflammation, insulinaemia and endothelial dysfunction were measured in blood and urine from 46 RA patients and 48 age-matched controls. Plaque formation and intima-medial thickness IMT were measured using B-mode carotid Doppler scan.

FindingsThe prevalence of plaque was increased p = 0.042 in RA patients between 50–59 years old compared to the same age group in controls. 8-isoprostane p = 0.004, C-reactive protein p < 0.001, interleukin-6 p < 0.001, insulin p = 0.035, adiponectin p = 0.012, vascular cell adhesion molecule VCAM p = 0.029 and E-selectin p < 0.001 were all increased while selenium p = 0.003 and LDL-cholesterol p = 0.025 were both decreased in all RA patients. 8-isoprostane correlated with 10 year cardiac risk r = 0.55, p < 0.001, VCAM with IMT r = 0.37, p = 0.012 and E-selectin with rheumatoid factor titre r = 0.43, p = 0.003 in RA patients. In the control group, age, carotid IMT, VCAM, systolic blood pressure and smoking status were all associated with plaque development whereas in RA patients only age was associated with plaque.

ConclusionThe burden of atherosclerosis is particularly increased in middle-aged women with RA. Patients with RA have increased levels of oxidant stress, inflammation, insulin and soluble adhesion molecules. As the association between classical risk factors was much weaker in RA patients compared to controls, these additional factors may be more important in the accelerated development of atheroma in RA.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-2-83 contains supplementary material, which is available to authorized users.

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Autor: Philip W Pemberton - Yasmeen Ahmad - Helena Bodill - Daniel Lokko - Samantha L Hider - Allen P Yates - Michael G Walker

Fuente: https://link.springer.com/







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