Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinomaReportar como inadecuado

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BMC Cancer

, 15:743

First Online: 20 October 2015Received: 21 January 2015Accepted: 08 October 2015DOI: 10.1186-s12885-015-1727-6

Cite this article as: Tu, XP., Qiu, QH., Chen, LS. et al. BMC Cancer 2015 15: 743. doi:10.1186-s12885-015-1727-6


BackgroundNeutrophil-lymphocyte ratio NLR has been shown to be associated with prognosis in various solid tumors. This study aimed to evaluate the prognostic role of NLR in patients with laryngeal squamous cell carcinoma LSCC.

MethodsA total of 141 LSCC patients were retrospectively reviewed. Patients’ demographics were analyzed along with clinical and pathologic data. The optimal cutoff value of NLR was determined using receiver operating characteristic ROC curve analysis. The impact of the NLR and other potential prognostic factors on disease-free survival DFS and overall survival OS was assessed using the Kaplan-Meier method and multivariate Cox regression analysis.

ResultsThe optimal cutoff value of the NLR was 2.17. In the NLR ≤ 2.17 group, the 1-, 3-, and 5-year DFS rates were 88.2, 73.9 and 69.1 %, respectively, while in the NLR > 2.17 group, the DFS rates were 83.0, 54.6 and 49.2 %, respectively. Correspondingly, the 1-, 3-, and 5-year OS rates were 98.9, 85.1 and 77.4 % in the NLR ≤ 2.17 group and 97.9, 63.8 and 53.3 % in the NLR > 2.17 group, respectively. The multivariate Cox proportional hazard model analysis showed that NLR > 2.17 was a prognostic factor for both DFS hazard ratio HR = 1.869; 95 % confidence interval CI 1.078–3.243; P = 0.026 and OS HR =2.177; 95 % CI 1.208–3.924; P = 0.010.

ConclusionOur results showed that elevated preoperative NLR was an independent predictor of poor prognosis for patients with LSCC after surgical resection.

KeywordsLaryngeal squamous cell carcinoma Neutrophil-lymphocyte ratio Prognostic marker AbbreviationsNLRNeutrophil-lymphocyte ratio

LSCCLaryngeal squamous cell carcinoma

ROCReceive operating characteristic

DFSDisease-free survival

OSOverall survival

HRHazard ratio

CIConfidence interval

G-CSFGranulocyte-colony stimulating factor

BLLBenign laryngeal lesion

PLLPrecancerous laryngeal lesion

VEGFVascular endothelial growth factor


MMPMatrix metalloproteinase

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Autor: Xiu-Ping Tu - Qian-Hui Qiu - Liang-Si Chen - Xiao-Ning Luo - Zhong-Ming Lu - Si-Yi Zhang - Shao-Hua Chen


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