Trypanosoma cruzi: Inhibition of parasite growth and respiration by oxazolothiazolopyridine derivatives and its relationship to redox potential and lipophilicityReportar como inadecuado




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Resumen

Chagas- disease constitutes a therapeutic challenge because presently available drugs have wide toxicity to the host and are generally ineffective in the chronic stages of the disease. A series of oxazolothiazolopyridene derivatives were studied on Trypanosoma cruzi epimastigote growth and oxygen consumption and their electrochemical redox potentials and lipophilicity. The derivatives produced different degrees of parasite growth and respiration inhibition on CL Brener, LQ, and Tulahuen strains of T. cruzi epimastigotes. Respiratory chain inhibition appears to be a determinant of the trypanosomicidal activity of these compounds, since a significant correlation between respiration and culture growth inhibition was found. A similar correlation was found, within the different structural subfamilies, between toxic effects and the ability of the compounds to be oxidized in aqueous media. The inhibition of respiration and of parasite growth in culture increases with the lipophilicity of the substituents on the oxazolopyridine nucleus. No difference in the action of these derivatives was found among the different parasite strains. It is concluded that these compounds may have a potential usefulness in the treatment of Chagas- disease.



Autor: Maya Arango, Juan; - Morello Casté, Antonio; - Rodríguez, A.; - Núñez Vergara, Luis; - Repetto Scaramelli, Yolanda; - Puebla

Fuente: http://repositorio.uchile.cl/



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