Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostatsReportar como inadecuado




Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cancer

, 9:89

First Online: 23 March 2009Received: 17 October 2008Accepted: 23 March 2009DOI: 10.1186-1471-2407-9-89

Cite this article as: Baker, S.G., Soto, A.M., Sonnenschein, C. et al. BMC Cancer 2009 9: 89. doi:10.1186-1471-2407-9-89

Abstract

BackgroundThere is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrupted interactions are hypothesized to be mediated by molecules, termed morphostats, which diffuse through the tissue to determine cell phenotype and maintain tissue architecture.

MethodsWe developed a computer simulation based on simple properties of cell renewal and morphostats.

ResultsUnder the computer simulation, the disruption of the morphostat gradient in the stroma generated epithelial precursors of cancer without any mutation in the epithelium.

ConclusionThe model is consistent with the possibility that the accumulation of genetic and epigenetic changes found in tumors could arise after the formation of a founder population of aberrant cells, defined as cells that are created by low or insufficient morphostat levels and that no longer respond to morphostat concentrations. Because the model is biologically plausible, we hope that these results will stimulate further experiments.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-9-89 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Stuart G Baker - Ana M Soto - Carlos Sonnenschein - Antonio Cappuccio - John D Potter - Barnett S Kramer

Fuente: https://link.springer.com/







Documentos relacionados