Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in manReport as inadecuate

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BMC Research Notes

, 2:45

First Online: 20 March 2009Received: 19 August 2008Accepted: 20 March 2009DOI: 10.1186-1756-0500-2-45

Cite this article as: Åkerman, U. & Edvinsson, L. BMC Res Notes 2009 2: 45. doi:10.1186-1756-0500-2-45


BackgroundClinical observations have revealed that patients throw up undigested paracetamol tablets several hours following intake of rosehip drink with Lp299v Proviva. The purpose of this study was to demonstrate if this translates into altered plasma levels of paracetamol in nineteen healthy subjects consuming 200 ml of water, Rose hip drink or Proviva together with 1.5 gram of paracetamol.

FindingsThe concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 μmol-l was reached a 95% confidence interval of 57,161. The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 μmol-l 95% confidence intervals contain only zero for both rosehip treatments. There were significant differences in AUC, maximal paracetamol concentration and in time to maximal paracetamol concentration. The median maximal paracetamol concentration was 147 μmol-l for water, which is significantly higher than the median for rosehip drink with Lp299v,113.5 μmol-l, and than the median for rosehip-drink without Lp299v, 106.5 μmol-l p = 0.002, and p = 0.003; there were no significant difference between rosehip drink with or without Lp299v p > 0.3.

ConclusionWe have demonstrated an interaction between the uptake of paracetamol and the solvent in rosehip drink-Provia which mainly consists of long chain carbohydrates. This may in the clinic translate to the use of more drug than it is necessary.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-2-45 contains supplementary material, which is available to authorized users.

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Author: Ulrika Åkerman - Lars Edvinsson


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