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BMC Research Notes

, 2:44

First Online: 19 March 2009Received: 23 January 2009Accepted: 19 March 2009DOI: 10.1186-1756-0500-2-44

Cite this article as: Abdel Fattah, N.S., Hassan, H.E., Galal, Z.A. et al. BMC Res Notes 2009 2: 44. doi:10.1186-1756-0500-2-44

Abstract

BackgroundAnti-cyclic citrullinated peptides anti-CCP are highly specific diagnostic and prognostic markers for rheumatoid arthritis RA. They have been also found in psoriatic arthritis PsA, with controversies as regards clinical and radiological associations. The current study assessed anti-CCP in PsA and determined its clinical and radiological associations.

MethodsFour groups contributed to this study. 40 PsA, 40 psoriasis without arthritis, 40 RA and 40 healthy controls. They were tested for anti-CCP. Clinical and radiological data were collected and statistically compared between anti-CCP-positive and -negative PsA patients.

ResultsSeven PsA 17.5% and 34 RA 85% were seropositive for anti-CCP. Patients of other groups were anti-CCP-negative. Regarding anti-CCP concentrations, highly significant difference existed between different groups and between anti-CCP-positive and -negative PsA. Significantly higher numbers of involved, swollen and tender joints, deformities and functional impairment of peripheral joints and radiological changes were found in anti-CCP-positive PsA.

ConclusionAnti-CCP may be found in PsA and are associated with higher number of involved, swollen and tender joints, with deformities and functional impairment of peripheral joints and with erosive arthritis.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-2-44 contains supplementary material, which is available to authorized users.

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Autor: Nermeen SA Abdel Fattah - Hanan E Hassan - Zenab A Galal - El Sayed E El Okda

Fuente: https://link.springer.com/







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