RAGE Receptor for Advanced Glycation Endproducts, RAGE Ligands, and their role in Cancer and InflammationReport as inadecuate

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Journal of Translational Medicine

, 7:17

First Online: 17 March 2009Received: 09 January 2009Accepted: 17 March 2009DOI: 10.1186-1479-5876-7-17

Cite this article as: Sparvero, L.J., Asafu-Adjei, D., Kang, R. et al. J Transl Med 2009 7: 17. doi:10.1186-1479-5876-7-17


The Receptor for Advanced Glycation Endproducts RAGE is an evolutionarily recent member of the immunoglobulin super-family, encoded in the Class III region of the major histocompatability complex. RAGE is highly expressed only in the lung at readily measurable levels but increases quickly at sites of inflammation, largely on inflammatory and epithelial cells. It is found either as a membrane-bound or soluble protein that is markedly upregulated by stress in epithelial cells, thereby regulating their metabolism and enhancing their central barrier functionality. Activation and upregulation of RAGE by its ligands leads to enhanced survival. Perpetual signaling through RAGE-induced survival pathways in the setting of limited nutrients or oxygenation results in enhanced autophagy, diminished apoptosis, and with ATP depletion necrosis. This results in chronic inflammation and in many instances is the setting in which epithelial malignancies arise. RAGE and its isoforms sit in a pivotal role, regulating metabolism, inflammation, and epithelial survival in the setting of stress. Understanding the molecular structure and function of it and its ligands in the setting of inflammation is critically important in understanding the role of this receptor in tumor biology.

Electronic supplementary materialThe online version of this article doi:10.1186-1479-5876-7-17 contains supplementary material, which is available to authorized users.

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Author: Louis J Sparvero - Denise Asafu-Adjei - Rui Kang - Daolin Tang - Neilay Amin - Jaehyun Im - Ronnye Rutledge - Brenda Lin

Source: https://link.springer.com/

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