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Reference: Qian, B, Deng, Y, Im, JH et al., (2009). A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PloS one, 4 (8), e6562.Citable link to this page:

 

A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth.

Abstract: BACKGROUND: The stromal microenvironment and particularly the macrophage component of primary tumors influence their malignant potential. However, at the metastatic site the role of these cells and their mechanism of actions for establishment and growth of metastases remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Using animal models of breast cancer metastasis, we show that a population of host macrophages displaying a distinct phenotype is recruited to extravasating pulmonary metastatic cells regardless of species of origin. Ablation of this macrophage population through three independent means (genetic and chemical) showed that these macrophages are required for efficient metastatic seeding and growth. Importantly, even after metastatic growth is established, ablation of this macrophage population inhibited subsequent growth. Furthermore, imaging of intact lungs revealed that macrophages are required for efficient tumor cell extravasation. CONCLUSION/SIGNIFICANCE: These data indicate a direct enhancement of metastatic growth by macrophages through their effects on tumor cell extravasation, survival and subsequent growth and identifies these cells as a new therapeutic target for treatment of metastatic disease.

Publication status:Published

Bibliographic Details

Journal: PloS onesee more from them

Issue Date: 2009

pages:e6562Identifiers

Urn: uuid:05b8c843-53d1-4b27-8753-beb825cb9511

Source identifier: 131393

Eissn: 1932-6203

Doi: https://doi.org/10.1371/journal.pone.0006562

Issn: 1932-6203 Item Description

Type: Journal article;

Language: eng Keywords: Animals Mice Macrophages Mammary Neoplasms, Experimental Neoplasm Metastasis Disease Models, Animal Cell Division Antigens, CD11b Female Tiny URL: pubs:131393

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Autor: Qian, B - - - Deng, Y - - - Im, JH - - - Muschel, RJ - institutionUniversity of Oxford Oxford, MSD, Oncology - - - Zou, Y - - - L

Fuente: https://ora.ox.ac.uk/objects/uuid:05b8c843-53d1-4b27-8753-beb825cb9511



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