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Reference: Frise, MC and Robbins, PA, (2015). Iron, oxygen, and the pulmonary circulation. Journal of Applied Physiology, 119 (12), 1421-1431.Citable link to this page:


Iron, oxygen, and the pulmonary circulation.

Abstract: The human pulmonary vasculature vasoconstricts in response to a reduction in alveolar oxygen tension, a phenomenon termed hypoxic pulmonary vasoconstriction (HPV). This review describes the time course of this behavior, which occurs in distinct phases, and then explores the importance for HPV of the hypoxia-inducible factor (HIF) pathway. Next, the HIF-hydroxylase enzymes that act as molecular oxygen sensors within the HIF pathway are discussed. These enzymes are particularly sensitive to intracellular iron availability, which confers iron-sensing properties on the HIF pathway. Human studies of iron chelation and supplementation are then reviewed. These demonstrate that the iron sensitivity of the HIF pathway evident from in vitro experiments is relevant to human pulmonary vascular physiology. Next, the importance of iron status in high-altitude illness and chronic cardiopulmonary disease is explored, and the therapeutic potential of intravenous iron discussed. The review concludes by highlighting some further complexities that arise from interactions between the HIF pathway and other intracellular iron-sensing mechanisms.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: National Institute for Health Research   Funder: British Heart Foundation   Notes:Licensed under Creative Commons Attribution CC-BY 3.0: © the American Physiological Society.

Bibliographic Details

Publisher: American Physiological Society

Publisher Website:

Journal: Journal of Applied Physiologysee more from them

Publication Website:

Issue Date: 2015-12


Urn: uuid:05316df5-d28b-426a-bc51-ed59b6a0838a

Source identifier: 527163

Eissn: 1522-1601


Issn: 8750-7587 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: high-altitude illness hypoxia hypoxia-inducible factor hypoxic pulmonary vasoconstriction iron Tiny URL: pubs:527163


Autor: Frise, MC - institutionUniversity of Oxford Oxford, MSD, Physiology Anatomy and Genetics - - - Robbins, PA - institutionUniversit



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