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Reference: Beckmann, BM, Castello, A and Medenbach, J, (2016). The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions. Pflügers Archiv European Journal of Physiology, 468 (6), 1029-1040.Citable link to this page:

 

The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions

Abstract: Post-transcriptional regulation of gene expression plays a critical role in almost all cellular processes. Regulation occurs mostly by RNA-binding proteins (RBPs) that recognise RNA elements and form ribonucleoproteins (RNPs) to control RNA metabolism from synthesis to decay. Recently, the repertoire of RBPs was significantly expanded owing to methodological advances such as RNA interactome capture. The newly identified RNA binders are involved in diverse biological processes and belong to a broad spectrum of protein families, many of them exhibiting enzymatic activities. This suggests the existence of an extensive crosstalk between RNA biology and other, in principle unrelated, cell functions such as intermediary metabolism. Unexpectedly, hundreds of new RBPs do not contain identifiable RNA-binding domains (RBDs), raising the question of how they interact with RNA. Despite the many functions that have been attributed to RNA, our understanding of RNPs is still mostly governed by a rather protein-centric view, leading to the idea that proteins have evolved to bind to and regulate RNA and not vice versa. However, RNPs formed by an RNA-driven interaction mechanism (RNA-determined RNPs) are abundant and offer an alternative explanation for the surprising lack of classical RBDs in many RNA-interacting proteins. Moreover, RNAs can act as scaffolds to orchestrate and organise protein networks and directly control their activity, suggesting that nucleic acids might play an important regulatory role in many cellular processes, including metabolism.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionNotes:Copyright The Author(s) 2016. This article is distributed under the terms of the CreativeCommons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,distribution, and reproduction in any medium, provided you give appropriatecredit to the original author(s) and the source, provide a link to theCreative Commons license, and indicate if changes were made.

Bibliographic Details

Publisher: Springer Berlin Heidelberg

Publisher Website: jhttp://www.springer.com/

Journal: Pflügers Archiv European Journal of Physiologysee more from them

Publication Website: http://link.springer.com/journal/424

Volume: 468

Issue: 6

Extent: 1029-1040

Issue Date: 2016

pages:1029-1040Identifiers

Urn: uuid:1423dd45-4be9-455e-a087-05ec9cfa7a42

Source identifier: 614231

Issn: 0031-6768

Eissn: 1432-2013

Doi: https://doi.org/10.1007/s00424-016-1819-4 Item Description

Type: Journal article;

Version: Publisher's versionKeywords: RNA-binding proteins protein-RNA interaction ribonucleoproteins interactome capture RNA binding domain RNA-determined RNPs Tiny URL: pubs:614231

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Autor: Beckmann, BM - - - Castello, A - institutionUniversity of Oxford Oxford, MSD, Biochemistry fundingMedical Research Council grantN

Fuente: https://ora.ox.ac.uk/objects/uuid:1423dd45-4be9-455e-a087-05ec9cfa7a42



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