Effect of Heterogeneous Mixing and Vaccination on the Dynamics of Anthelmintic Resistance: A Nested Model - Quantitative Biology > Populations and EvolutionReportar como inadecuado




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Abstract: Anthelmintic resistance is a major threat to current measures for helminthcontrol in humans and animals. The introduction of anthelmintic vaccines, as acomplement to or replacement for drug treatments, has been advocated as apreventive measure. Here, a computer-based simulation, tracking the dynamics ofhosts, parasites and parasite-genes, shows that, depending on the degree ofhost-population mixing, the frequency of totally recessive autosomes associatedwith anthelmintic resistance can follow either a fast dynamical regime with alow equilibrium point or a slow dynamical regime with a high equilibrium point.For fully dominant autosomes, only one regime is predicted. The effectivenessof anthelminthic vaccines against resistance is shown to be strongly influencedby the underlying dynamics of resistant autosomes. Vaccines targeting adultparasites, by decreasing helminth fecundity or lifespan, are predicted to bemore effective than vaccines targeting parasite larvae, by decreasing hostsusceptibility to infection, in reducing the spread of resistance. Theseresults may inform new strategies to prevent, monitor and control the spread ofanthelmintic resistance, including the development of viable anthelminticvaccines.



Autor: Lorenzo Sabatelli

Fuente: https://arxiv.org/







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