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Reference: Banks, G, Heise, I, Starbuck, B et al., (2015). Genetic background influences age-related decline in visual and nonvisual retinal responses, circadian rhythms, and sleep. Neurobiology of aging, 36 (1), 380-393.Citable link to this page:

 

Genetic background influences age-related decline in visual and nonvisual retinal responses, circadian rhythms, and sleep.

Abstract: The circadian system is entrained to the environmental light/dark cycle via retinal photoreceptors and regulates numerous aspects of physiology and behavior, including sleep. These processes are all key factors in healthy aging showing a gradual decline with age. Despite their importance, the exact mechanisms underlying this decline are yet to be fully understood. One of the most effective tools we have to understand the genetic factors underlying these processes are genetically inbred mouse strains. The most commonly used reference mouse strain is C57BL/6J, but recently, resources such as the International Knockout Mouse Consortium have started producing large numbers of mouse mutant lines on a pure genetic background, C57BL/6N. Considering the substantial genetic diversity between mouse strains we expect there to be phenotypic differences, including differential effects of aging, in these and other strains. Such differences need to be characterized not only to establish how different mouse strains may model the aging process but also to understand how genetic background might modify age-related phenotypes. To ascertain the effects of aging on sleep/wake behavior, circadian rhythms, and light input and whether these effects are mouse strain-dependent, we have screened C57BL/6J, C57BL/6N, C3H-HeH, and C3H-Pde6b+ mouse strains at 5 ages throughout their life span. Our data show that sleep, circadian, and light input parameters are all disrupted by the aging process. Moreover, we have cataloged a number of strain-specific aging effects, including the rate of cataract development, decline in the pupillary light response, and changes in sleep fragmentation and the proportion of time spent asleep.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:Copyright © 2015 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). Open Access funded by Medical Research Council.

Bibliographic Details

Publisher: Elsevier

Publisher Website: http://www.elsevier.com/

Journal: Neurobiology of agingsee more from them

Publication Website: http://www.journals.elsevier.com/neurobiology-of-aging

Issue Date: 2015-01

pages:380-393Identifiers

Urn: uuid:2f7be2a1-3ee5-4f80-b3d0-4c398b38ccce

Source identifier: 483217

Eissn: 1558-1497

Doi: https://doi.org/10.1016/j.neurobiolaging.2014.07.040

Issn: 0197-4580 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Aging Circadian Light input Mouse strain Sleep Tiny URL: pubs:483217

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Autor: Banks, G - - - Heise, I - - - Starbuck, B - - - Osborne, T - - - Wisby, L - - - Potter, P - - - Jackson, IJ - - - Foster, RG - in

Fuente: https://ora.ox.ac.uk/objects/uuid:2f7be2a1-3ee5-4f80-b3d0-4c398b38ccce



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