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Reference: Bejon, P, Turner, L, Lavstsen, T et al., (2011). Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites. PloS one, 6 (6), Article: e21711.Citable link to this page:


Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites.

Abstract: BACKGROUND: Malaria transmission may be considered to be homogenous with well-mixed parasite populations (as in the classic Ross/Macdonald models). Marked fine-scale heterogeneity of transmission has been observed in the field (i.e., over a few kilometres), but there are relatively few data on the degree of mixing. Since the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is highly polymorphic, the host's serological responses may be used to infer exposure to parasite sub-populations. METHODS AND FINDINGS: We measured the antibody responses to 46 individual PfEMP1 domains at four time points among 450 children in Kenya, and identified distinct spatial clusters of antibody responses to individual domains. 35 domains showed strongly significant sero-clusters at p = 0.001. Individuals within the high transmission hotspot showed the greatest diversity of anti-PfEMP1 responses. Individuals outside the hotspot had a less diverse range of responses, even if as individuals they were at relatively intense exposure. CONCLUSIONS: We infer that antigenically distinct sub-populations of parasites exist on a fine spatial scale in a study area of rural Kenya. Further studies should examine antigenic variation over longer periods of time and in different study areas.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: PATH Malaria Vaccine Initiative   Funder: GlaxoSmithKline Biologicals   Funder: Foundation for the National Institutes of Health   Funder: University of Copenhagen Program of Excellence   Funder: NIHR Biomedical Research Centre Oxford   Notes:Copyright 2011 Bejon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Bibliographic Details

Publisher: Public Library of Science

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Journal: PloS onesee more from them

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Issue Date: 2011

pages:Article: e21711Identifiers

Urn: uuid:361ea51f-a8bd-480e-8ce0-7012a8476ad4

Source identifier: 166440

Eissn: 1932-6203


Issn: 1932-6203 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Animals Humans Plasmodium falciparum Malaria Protozoan Proteins Cluster Analysis Serologic Tests Aging Infant Antibody Formation Principal Component Analysis Time Factors Tiny URL: pubs:166440


Autor: Bejon, P - institutionUniversity of Oxford Oxford, MSD, Clinical Medicine, Jenner Institute fundingNIHR Biomedical Research Centr



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