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Reference: Galson, JD, Pollard, AJ, Trück, J et al., (2014). Studying the antibody repertoire after vaccination: practical applications. Trends in Immunology, 35 (7), 319-331.Citable link to this page:


Studying the antibody repertoire after vaccination: practical applications.

Abstract: Nearly all licensed vaccines have been developed to confer protection against infectious diseases by stimulating the production of antibodies by B cells, but the nature of a successful antibody response has been difficult to capture. Recent advances in next-generation sequencing (NGS) technology have allowed high-resolution characterization of the antibody repertoire, and of the changes that occur following vaccination. These approaches have yielded important insights into the B cell response, and have raised the possibility of using specific antibody sequences as measures of vaccine immunogenicity. Here, we review recent findings based on antibody repertoire sequencing, and discuss potential applications of these new technologies and of the analyses of the increasing volume of antibody sequence data in the context of vaccine development.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Accepted manuscriptNotes:© 2014 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: [10.1016/]

Bibliographic Details

Publisher: Elsevier (Cell Press)

Publisher Website:

Journal: Trends in Immunologysee more from them

Publication Website:

Issue Date: 2014-05-21


Urn: uuid:4abc82de-ff9b-4fed-b398-d42e3a9d10fc

Source identifier: 466144

Eissn: 1471-4981


Issn: 1471-4906 Item Description

Type: Journal article;

Language: eng

Version: Accepted manuscriptKeywords: B-Lymphocytes Animals Humans Vaccines Vaccination Antibody Formation Immunity, Active Genes, Immunoglobulin Drug Discovery High-Throughput Nucleotide Sequencing Tiny URL: pubs:466144


Autor: Galson, JD - institutionUniversity of Oxford Oxford, MSD, Paediatrics grantNumberGlaxoSmithKline fundingBiotechnology and Biologi



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