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Reference: Lin, J, Yang, L, Silva, HM et al., (2016). Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus. Nature communications, 7, 10562.Citable link to this page:

 

Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.

Abstract: Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases. Although important rules for Treg selection have been established, there is controversy regarding the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells. In this study we have developed a model of autoimmune skin inflammation, to determine key parameters in the generation of skin-reactive Treg cells in the thymus (tTreg). tTreg development is predominantly AIRE dependent, with an AIRE-independent component. Without the knowledge of antigen recognized by skin-reactive Treg cells, we are able to enhance skin-specific tTreg cell generation using three approaches. First, we increase medullary thymic epithelial cells by using mice lacking osteoprotegerin or by adding TRANCE (RANKL, Tnfsf11). Second, we inject intrathymically peripheral dendritic cells from skindraining sites. Finally, we inject skin tissue lysates intrathymically. These findings have implications for enhancing the generation of organ-specific Treg cells in autoimmune diseases.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Laura and Isaac Perlmutter Cancer Center.   Notes:© 2016 Dustin et al. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website: http://www.nature.com/

Journal: Nature communicationssee more from them

Publication Website: http://www.nature.com/ncomms/

Issue Date: 2016-02

Article Number:ARTN 10562

pages:10562Identifiers

Urn: uuid:512354fa-bb2a-4feb-82c7-c20e96529b07

Source identifier: 609262

Eissn: 2041-1723

Doi: https://doi.org/10.1038/ncomms10562

Issn: 2041-1723 Item Description

Type: Journal article;

Language: eng

Version: Publisher's version Tiny URL: pubs:609262

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Autor: Lin, J - - - Yang, L - - - Silva, HM - - - Trzeciak, A - - - Choi, Y - - - Schwab, SR - - - Dustin, ML - institutionUniversity of

Fuente: https://ora.ox.ac.uk/objects/uuid:512354fa-bb2a-4feb-82c7-c20e96529b07



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