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Reference: Yakob, L, Bonsall, MB, Yan, G et al., (2010). Modelling knowlesi malaria transmission in humans: Vector preference and host competence. Malaria Journal, 9 (1), Article: 329.Citable link to this page:

 

Modelling knowlesi malaria transmission in humans: Vector preference and host competence

Abstract: Background: Plasmodium knowlesi, a malaria species that normally infects long-tailed macaques, was recently found to be prevalent in humans in Southeast Asia. While human host competency has been demonstrated experimentally, the extent to which the parasite can be transmitted from human back to mosquito vector in nature is unclear. Methods. Using a mathematical model, the influence of human host competency on disease transmission is assessed. Adapting a standard model for vector-borne disease transmission and using an evolutionary invasion analysis, the paper explores how differential host competency between humans and macaques can facilitate the epidemiological processes of P. knowlesi infection between different hosts. Results. Following current understanding of the evolutionary route of other human malaria vectors and parasites, an increasing human population in knowlesi malaria endemic regions will select for a more anthropophilic vector as well as a parasite that preferentially transmits between humans. Applying these adaptations, evolutionary invasion analysis yields threshold conditions under which this macaque disease may become a significant public health issue. Conclusions. These threshold conditions are discussed in the context of malaria vector-parasite co-evolution as a function of anthropogenic effects. © 2010 Yakob et al; licensee BioMed Central Ltd.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:© 2010 Yakob et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: BioMed Central Ltd.

Publisher Website: http://www.biomedcentral.com/

Journal: Malaria Journalsee more from them

Publication Website: http://www.malariajournal.com/

Issue Date: 2010

pages:Article: 329Identifiers

Urn: uuid:608c7bbe-0cb7-4148-948b-bb17f7f8c5f2

Source identifier: 211141

Eissn: 1475-2875

Doi: https://doi.org/10.1186/1475-2875-9-329 Item Description

Type: Journal article;

Language: eng

Version: Publisher's version Tiny URL: pubs:211141

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Autor: Yakob, L - - - Bonsall, MB - - - Yan, G - - - Bonsall, MB - institutionUniversity of Oxford Oxford, MPLS, Zoology fundingRoyal So

Fuente: https://ora.ox.ac.uk/objects/uuid:608c7bbe-0cb7-4148-948b-bb17f7f8c5f2



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