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Reference: Lidster, K, Jefferys, JG, Blümcke, I et al., (2015). Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods.Citable link to this page:

 

Opportunities for improving animal welfare in rodent models of epilepsy and seizures

Abstract: Animal models of epilepsy and seizures, mostly involving mice and rats, are used to understand the pathophysiology of the different forms of epilepsy and their comorbidities, to identify biomarkers, and to discover new antiepileptic drugs and treatments for comorbidities. Such models represent an important area for application of the 3Rs (replacement, reduction and refinement of animal use). This report provides background information and recommendations aimed at minimising pain, suffering and distress in rodent models of epilepsy and seizures in order to improve animal welfare and optimise the quality of studies in this area. The report includes practical guidance on principles of choosing a model, induction procedures, in vivo recordings, perioperative care, welfare assessment, humane endpoints, social housing, environmental enrichment, reporting of studies and data sharing. In addition, some model-specific welfare considerations are discussed, and data gaps and areas for further research are identified. The guidance is based upon a systematic review of the scientific literature, survey of the international epilepsy research community, consultation with veterinarians and animal care and welfare officers, and the expert opinion and practical experience of the members of a Working Group convened by the United Kingdom's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs).

Peer Review status:Peer reviewedPublication status:In pressVersion:Publisher's versionNotes:Copyright © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Bibliographic Details

Publisher: Elsevier

Publisher Website: http://www.elsevier.com/

Journal: Journal of Neuroscience Methodssee more from them

Publication Website: http://www.journals.elsevier.com/journal-of-neuroscience-methods

Issue Date: 2015Identifiers

Urn: uuid:638800b7-0cfc-4856-9acb-e50ad64da924

Source identifier: 571120

Doi: https://doi.org/10.1016/j.jneumeth.2015.09.007

Issn: 0165-0270 Item Description

Type: Journal article;

Version: Publisher's versionKeywords: 3Rs animal model epilepsy mouse rat refinement seizure Tiny URL: pubs:571120

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Autor: Lidster, K - - - Jefferys, JG - institutionUniversity of Oxford Oxford, MSD, Biochemistry - - - Blümcke, I - - - Crunelli, V - -

Fuente: https://ora.ox.ac.uk/objects/uuid:638800b7-0cfc-4856-9acb-e50ad64da924



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