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Reference: Lederman, ER, Maguire, JD, Sumawinata, IW et al., (2006). Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia. Malaria Journal, 5, Article: 108.Citable link to this page:

 

Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia.

Abstract: BACKGROUND: Chloroquine (CQ) or sulfadoxine-pyrimethamine (SP) monotherapy for Plasmodium falciparum often leads to therapeutic failure in Indonesia. Combining CQ with other drugs, like SP, may provide an affordable, available and effective option where artemisinin-combined therapies (ACT) are not licensed or are unavailable. METHODS: This study compared CQ (n = 29 subjects) versus CQ + SP (with or without primaquine; n = 88) for clinical and parasitological cure of uncomplicated falciparum malaria in the Menoreh Hills region of southern Central Java, Indonesia. Gametocyte clearance rates were measured with (n = 56 subjects) and without (n = 61) a single 45 mg dose of primaquine (PQ). RESULTS: After 28 days, 58% of subjects receiving CQ had cleared parasitaemia and remained aparasitaemic, compared to 94% receiving CQ combined with SP (p < 0.001). Msp-2 genotyping permitted reinfection-adjusted cure rates for CQ and CQ combined with SP, 70% and 99%, respectively (p = 0.0006). CONCLUSION: Primaquine exerted no apparent affect on cure of asexual stage parasitaemia, but clearly accelerated clearance of gametocytes. CQ combined with SP was safe and well-tolerated with superior efficacy over CQ for P. falciparum parasitaemia in this study.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Global Emerging Infections Surveillance and Response System   Notes:© 2006 Lederman et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: BioMed Central Ltd.

Publisher Website: http://www.biomedcentral.com/

Journal: Malaria Journalsee more from them

Publication Website: http://www.malariajournal.com/

Issue Date: 2006

pages:Article: 108Identifiers

Urn: uuid:6e57945e-c87b-4957-97bb-c8cf6afcf699

Source identifier: 81715

Eissn: 1475-2875

Doi: https://doi.org/10.1186/1475-2875-5-108

Issn: 1475-2875 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Animals Humans Plasmodium falciparum Malaria, Falciparum Primaquine Sulfadoxine Drug Combinations Drug Therapy, Combination Adolescent Adult Antimalarials Middle Aged Chloroquine Pyrimethamine Indonesia Female Male Tiny URL: pubs:81715

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Autor: Lederman, ER - - - Maguire, JD - - - Sumawinata, IW - - - Chand, K - - - Elyazar, I - - - Estiana, L - - - Sismadi, P - - - Bangs

Fuente: https://ora.ox.ac.uk/objects/uuid:6e57945e-c87b-4957-97bb-c8cf6afcf699



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